Molecular-Based Recursive Partitioning Analysis Model for Glioblastoma in the Temozolomide Era
نویسندگان
چکیده
منابع مشابه
Model-based Recursive Partitioning
Recursive partitioning is embedded into the general and well-established class of parametric models that can be fitted using M-type estimators (including maximum likelihood). An algorithm for model-based recursive partitioning is suggested for which the basic steps are: (1) fit a parametric model to a data set, (2) test for parameter instability over a set of partitioning variables, (3) if ther...
متن کاملCLINICAL STUDY – PATIENT STUDY Radiotherapy and temozolomide for newly diagnosed glioblastoma and anaplastic astrocytoma: validation of Radiation Therapy Oncology Group-Recursive Partitioning Analysis in the IMRT and temozolomide era
Since the development of the Radiation Therapy Oncology Group-Recursive Partitioning Analysis (RTOGRPA) risk classes for high-grade glioma, radiation therapy in combination with temozolomide (TMZ) has become standard care. While this combination has improved survival, the prognosis remains poor in the majority of patients. Therefore, strong interest in high-grade gliomas from basic research to ...
متن کاملparty with the mob: Model-based Recursive Partitioning in R
The party package (Hothorn, Hornik, and Zeileis 2006) provides the function mob() implementing a recently suggested algorithm for model-based recursive partitioning (Zeileis, Hothorn, and Hornik 2005). The basic steps are: (1) fit a parametric model to a data set, (2) test for parameter instability over a set of partitioning variables, (3) if there is some overall parameter instability, split t...
متن کاملValidation and simplification of the Radiation Therapy Oncology Group recursive partitioning analysis classification for glioblastoma.
PURPOSE Previous recursive partitioning analysis (RPA) of patients with malignant glioma (glioblastoma multiforme [GBM] and anaplastic astrocytoma [AA]) produced six prognostic groups (I-VI) classified by six factors. We sought here to determine whether the classification for GBM could be improved by using an updated Radiation Therapy Oncology Group (RTOG) GBM database excluding AA and by consi...
متن کاملRadiotherapy and temozolomide for newly diagnosed glioblastoma: recursive partitioning analysis of the EORTC 26981/22981-NCIC CE3 phase III randomized trial.
PURPOSE The European Organisation for Research and Treatment of Cancer and National Cancer Institute of Canada trial on temozolomide (TMZ) and radiotherapy (RT) in glioblastoma (GBM) has demonstrated that the combination of TMZ and RT conferred a significant and meaningful survival advantage compared with RT alone. We evaluated in this trial whether the recursive partitioning analysis (RPA) ret...
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ژورنال
عنوان ژورنال: JAMA Oncology
سال: 2017
ISSN: 2374-2437
DOI: 10.1001/jamaoncol.2016.6020